Discovery of C. glutamicum, a Glutamic Acid-Producing Bacterium

Discovery of C. glutamicum, a Glutamic Acid-Producing Bacterium 

Production of glutamic acid by microbial cells was first achieved in a two-stage production process first, 2-oxoglutarate was produced by microorganisms, and then glutamic acid was produced enzymatically from 2-oxoglutarate as a substrate. However, since this two-stage process was not ideal for industrial-scale 

One of the key strategies in screening for glutamic acid-producing microorganisms was the use of the amino acid auxotrophic lactic acid bacterium Leuconostoc 

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