Discovery Development Interface Water Solubility

The discovery development interface is important with respect to drug aqueous solubihty. In earlier discovery stages kinetic solubihty assays are perfectly acceptable even more desirable than the thermodynamic equilibrium solubihty assay. 

As projects approach decision points regarding oral absorption solubihty assays must change towards the traditional thermodynamic equilibrium solubihty assay. Stated again for emphasis - the early discovery kinetic solubihty assay is not a replacement for a traditional thermodynamic equilibrium solubihty assay. Accurate oral absorption requires testing of crystalline materials and corresponding accurate solubihty testing of crystalline materials. 

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