Disconnections overview

After having set the stage of the workshop, an overview of the case and the decision criteria for riser disconnection were presented. This was followed by a presentation of the STEP-analysis, i.e. Sequentially Timed Events Plotting (Hendrick and Beimer, 1987) as a method to analyse scenarios. STEP-analysis is an accident investigation method involving a detailed mapping out of a scenario (accident) by plotting the... 

Abstract Retrosynthetic analysis as an imaginative process is introduced. Disconnection and functional group interconversion are discussed. l-(Pyridine-3-yl) propan-l-ol is selected as an exemplary target molecule for retrosynthetic analysis and its (5 -enantiomer for asymmetric synthesis. Interconversions of oxygen functionalities are overviewed. The acidity of the C-H bond as a key property for C-C disconnections is indicated. Some historical and environmental aspects of organic synthesis are concisely presented. 

Scheme 5.53 Overview of disconnections of the central C-C bonds in the 1,6-CO pattern...

This paper presents a nice "overview" of other approaches (13 key intermediates). The "plan" involves an interesting disconnection that is related to the Evans solution to the vicinal stereochemistry problem. The plan is great, but lack of selectivity in the orbital symmetry... 

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