Disappearance of metabolites

Starting fi om the fer past (Chapter 16.1), until our days (Ch ters 16.2.1-16.2.4), threats to natural product diversity are examined in the Tables 16.2.5.11-V, although disentangling the causes is seldom possible. A combination of various factors is usually responsible for the disappearance of metabolites. Threatening of natural product diversity has mostly political causes, first of all in permitting an indiscriminate use of the car. Therefore, the division of land into biomes, and the biological zonation of the oceans, have been abandoned in Tables 16.1.5.I1-V in favor of the geopolitical subdivision. 

Input to the system is the structural formula of the compound whose metabolism is to be studied. The structural formula is entered as a simplified form of the connectivity matrix (which is the standard chemical input of the LABSWARE program series, LABSWARE 1986) and requires no sophisticated graphics facilities. As the most important output, the chemical structures of the metabolites (coded in the same form as the input) are listed. In addition, asimplified graphic representation ofthe human body is produced as output. It shows the appearance and disappearance of metabolites in organs at different times. 

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