Disaccharides, furanosyl synthesis

An extensive report from Prinzbach s laboratory has described the synthesis of the pseudodisaccharide sannamycin (1), its 2-epimer and various other isomers, including the enantiomers of sannamycin and its 2-epimer. A detailed study was made of the glycosylations necessary to assemble these sytems. Various other novel pseudodisaccharides have also been prepared, including the a-D-arabino-furanosyl systems 2 (R=H, a-NHa, jJ-NHa), and the pyranose these workers also describe a Ferrier carbocyclization at the disaccharide level, using an acid labile 2 -deoxy-disaccharide, to give the aminocyclitol derivative 4. ... 

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