Direct Suzuki-Miyaura type reaction

Directed orf/to-metalation (DoM) chemistry [81] further reinforces the versatility of nickel-catalyzed C-O bond activation reactions. Based on the strong accelerating and orf/to-directing effect of carbamate functionality in the base-induced deprotonation of arenes, an array of electrophiles can be introduced at the ortho position of aryl carbamates. For instance, DoM of dicarbamate, followed by 1,2-addition to a,(3-unsaturated aldehyde and intramolecular cyclization, furnishes the 2//-chromene derivative (Scheme 8) [82]. The carbamate director can finally be arylated under a nickel-catalyzed Suzuki-Miyaura-type reaction [47]. 

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