1, 3-dipolar, nonstabilized azomethine ylides preparation

The preparation of pyrrolidines has received extensive attention by synthetic chemists in recent years, in part due to the interesting biological activities exhibited by several polysubstituted pyrrolidines. Little attention has been given to one of the most conceptually simple ways of pyrrolidine formation a 1,3-dipolar cycloaddition of an azomethine ylide with an olefin. This is not surprising since few methods exist for the preparation of nonstabilized azomethine ylides. " Silyl-substituted amines of Type 1 represent conjunctive reagents which can be considered as the equivalent of a nonstabilized azomethine ylide. These reagents have recently been found to... 

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