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1.3- Dipolar cycloaddition reactions nonconcerted

Cycloaddition of stericaUy crowded 2,2,4,4-tetramethyl-3-thioxocyclobutanone (5)-methylide (69) (Scheme 5.25) with extremely electron-poor dipolarophUes are of special interest with respect to the theory of dipolar cycloaddition chemistry. In these reactions, a nonconcerted, two-step mechanism was proposed (96,97). [Pg.327]

Cycloadditions may be pericyclic reactions or (nonconcerted) stepwise reactions. The term dipolar cycloaddition is used for cycloadditions of 1,3-dipolar compounds. [Pg.67]

To date, the Huisgen 1,3-dipolar cycloaddition is described as nonconcerted when catalysts, processing via metallacycle intermediates, are used, leading to snbstituted heterocycles in excellent selectivity (for specific examples, see Sections 9.2 and 9.5). The outstanding discovery of the Cu(I)-catalyzed azide-aUcyne cycloaddition by Meldal and Sharpless particularly improved the rates as well as the regioselectivity of the reaction (see subsequent chapter) and is now the most commonly used 1,3-dipolar cycloaddition in organic synthesis. ... [Pg.270]


See other pages where 1.3- Dipolar cycloaddition reactions nonconcerted is mentioned: [Pg.649]    [Pg.1075]    [Pg.544]    [Pg.246]    [Pg.82]    [Pg.1006]    [Pg.1006]   
See also in sourсe #XX -- [ Pg.4 ]

See also in sourсe #XX -- [ Pg.4 ]




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1.3- Dipolar reactions

Cycloaddition reactions 1,3-dipolar

Cycloaddition reactions, nonconcerted

Cycloadditions 1,3-dipolar reactions

Nonconcerted

Nonconcerted reactions

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