Diplodialides, macrolides

Simple Monocyclic Macrolides A. Recifeioltide Diplodialides Lasiodiplodin Curvularin Zearalenone Brefeldin A... 

A route to /3-keto-macrolides, based on some earlier work of Eschenmoser, involves an intramolecular C—S rather than C—O bond formation (Scheme 11). High dilution conditions are necessary, with yields varying between 25 and 58% this approach may be expedient with polyfunctional molecules as a variety of functional groups (e.g. olefins, acetylenes, esters, ketones, acetals) are unaffected by the reagents used. Diplodialide A has been prepared by this route. 

The method of synthesis of macrolides by cyclization of w-hydroxycarboxylic acids has had its successes this year in the preparation of A26771B, carbomycin josamycin, and the diplodialides A and B. ° Well known activation techniques were applied in all cases, and the interest in these papers lies largely with the preliminary manipulations necessary to set up appropriately... 

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