Diphyllin acetate

Carragenin-induced paw edema and 12-0-tetradecanoylphorbol 13-acetate (TPA)-induced edema have been used as experimental models of acute inflammation. Gomisin A (49), gomisin J (140), and wuweizisu C (141) inhibited inflammation induced by TPA in mice [44], Diphyllin acetyl apioside (142) and diphyllin apioside (tuberculatin) (143) also showed an anti-inflammatory effect with IDjg values of 0.27 and 1.23 pM/ ear, respectively, in rabbit [98]. 

Justicidins A and B, diphyllin, diphyllin apioside and diphyllin apioside-5-acetate from of Justicia procumbens var. leucantha (Acanthaceae) showed strong antiviral activity, with a minimum inhibitory concentration (MIC) of 0.13, > 0.06, 0.25, 0.25 and 0.13 pg/mL, respectively, against VSV, and they had low cytotoxicity [167]. 

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