Diphenylphosphino 2- -4-phenyloxazoline

As described in many reviews, Trost and his co-workers have carried out a pioneering work on the molybdenum-and tungsten-catalyzed allylic alkylation of allylic esters regioselectivity of the reaction is often complementary to the palladium-catalyzed allylic alkylation. The first asymmetric version was disclosed by Pfaltz and Lloyd-Jones in 1995 (Equation (63)). They used a catalytic amount of a novel tungsten complex, prepared from [W(CO)3(MeCN)3] or [W(cycloheptatriene) (COIs] and optically active (diphenylphosphino)phenyloxazolines 57, for the allylic alkylation of 3-aryl-2-propenyl phosphate with dimethyl sodiomalonate to isolate the corresponding branched alkylated compounds as a major isomer with an excellent enantioselectivity (96% ee). Unexpectedly, 3-aryl-2-propenyl carbonates are shown to be unreactive. It is worth noting that an isostructural molybdenum complex does not promote the catalytic alkylation under the same reaction conditions. In contrast, Lloyd-Jones and Lehmann reported the stereocontrolled... 

Related Reagents. (5,5)-2,2 -(Dimethylmethylene)bis-(4-/-butyl-2-oxazoline) Bis(dimethylglyoximato)(methyl)(pyridine)-cobalt(III) Copper(II) Trifluoromethanesulfonate (15,95)-1,9-Bis [(/-butyl)dimethylsilyloxy]methyl -5-cyanosemicorrin (5)-2-[2-(Diphenylphosphino)phenyl]-4-phenyloxazoline Ethyl Diazoacetate. 

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