Diphenyl-2,2 -dialdehyde

Reduction of the eight-membered ring peroxide (137) with potassium iodide in glacial acetic acid leads to an 84% yield of 2,2 -diphenyl-dialdehyde.141 The base-catalyzed decomposition of 137 gives 2,2 -diphenaldehydic acid in 84% yield. Diphenic acid (84%) is obtained when 139 is heated with a mixture of 30% hydrogen peroxide and 10% sodium hydroxide solution.141... 

Benzil-disulfon8aure-(3.3 ) 11, 335. Diphenyl-dialdehyd-(3.3 )-disnlftm 94nre-(4.4 ) 111 81. Anthrahydroohinon-disulfonB4ure-( 1.5)... 

There are four possible classes of bis-5(4H)-oxazolones (cf. 8-11). Compounds of type 8 may be prepared by the Erlenmeyer reaction on dialdehydes. The compound in which R is derived from the 4,4 -dialdehyde of diphenyl ether (R = CgHs) is a recent example. ... 

A peculiar reduction occurred on treatment of a dialdehyde, diphenyl-2,2 -dicarboxaldehyde, with tris(dimethylamino)phosphine at room temperature phenanthrene-9,10-oxide was formed in 81-89% yield [302],... 

Berbamine occurs in B. vulgaris, B. aquifolium (12, 13), B. thunbergii (22), Stephania cepharantha Hayata (23), and in B. swaseyi Buckley Mahonia swaseyi Fedde) to the extent of about 2 % in the dried roots (24). Santos (21) found that berbamine was isomeric with oxyacanthine and that oxidation of berbamine methyl ether produced 4, 5-dicarboxy-2-methoxy-diphenyl ether (VIII, R = CH3), as in the case of oxyacanthine. The constitution of the isoquinoline portion of the molecule was determined by von Bruchhausen, Oberembt, and Feldhaus (18). The products obtained after a Hofmann degradation of 0-methylberbamine followed by ozonization were the same two dialdehydes, XXXV and 4, 5-diformyl-2-methoxydiphenyl ether (XXXIV), as were obtained from 0-methyloxy-acanthine by similar treatment. On the basis of these facts von Bruchhausen and coworkers concluded that berbamine and oxyacanthine are structural isomers. If o.xyacanthine is assigned the formula XXVI then berbamine must have the formula XXXI or vice versa. 

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