Dipeptides, dendritic

Percec, V. et al. Principles of self-assembly of helical pores from dendritic dipeptides, Proc. Natl. Acad. Set USA., 103, 2518, 2006. [Pg.215]

The primary peptide structure brings options for sequence tailoring that generate specific functionalities and self-assembly characteristics. Examples are amphiphilic dendritic dipeptides making helical pores (Percec, 2006) ... [Pg.5]

Percec, V. Amphiphilic Dendritic Dipeptides and Their Self-Assembly into Helical Pores, 2005-171494 2006088499 (2006). [Pg.10]

The quaternary center of a dendritic tetramines 522 and 523 described by Feldman [128] was established through a Claisen-Johnson rearrangement of aUylic alcohol 524 (Scheme 6.81). One of the main steps in the synthesis of the protease inhibitor 526 [129] was achieved through a high-yield diastereoselective Claisen-Johnson rearrangement as described in Scheme 6.81. A stereoselective synthesis of the alkyUdene dipeptide isosteres 530 and 532 proceeded via a Claisen-Johnson rearrangement. It is worthy of note that yields with anti- or syn-configured ami-noalcohol derivatives 529 and 531 were quite different (Scheme 6.81) [130]. [Pg.357]

Dendritic Dipeptides as Aquaporin Transmembrane Protein Mimics. 188... [Pg.173]

Figure 11 outlines the structure of the homochiral enantiomers of the dendritic dipeptide, the CD and UV spectra as a function of temperature recorded in cyclohexane (a solvent that mimics the hydrophobic wall of the biological membrane and mediates self-assembly), and the structures of the supramolecular assemblies... [Pg.188]

Fig. 11 Structures of the homochiral dendritic dipeptides (a), their CD blue) and UV red) spectra recorded during self-assembly in cyclohexane (b, c), the nucleation and growth mechanism of cooperative supramolecular helical polymerization and the structures of the supramolecular assemblies (d). Modified with permission from [114]. Cop3right 2011 American Chemical Society...

Rosen BM, Roche C, Percec V (2013) Self-assembly of dendritic dipeptides as a model of chiral selection in primitive biological systems. Top Curr Chem 333 213-254. doi 10.1007/... [Pg.356]

Percec V, Dulcey AE, Balagurusamy VSK, Miura Y, Smidrkal J, Peterca M, Nuimnelin S, Edlund U, Hudson SD, Heiney PA, Duan H, Magonov SN, Vinogradov SA (2004) Self-assembly of amphiphilic dendritic dipeptides into helical pores. Nature 430(7001) 764—768. doi 10.1038Aiature02770... [Pg.358]

Percec V, Dulcey AE, Peterca M, Hies M, Ladislaw J, Rosen BM, Edlund U, Heiney PA (2005) The internal structure of helical pores self-assembled from dendritic dipeptides is stereochemically programmed and aUosteiicaUy regulated. Angew Chem bit Ed 44 (40) 6516-6521. doi 10.1002/anie.200501331... [Pg.358]

Peterca M, Percec V, Dulcey AE, Nummelin S, Ktuey S, Hies M, Heiney PA (2006) Self-assembly, structural, and retrostructural analysis of dendritic dipeptide pores undergoing reversible circular to elliptical shape change. J Am Chem Soc 128(20) 6713-6720. doi 10.1021/ja0611902... [Pg.358]

Percec V, Dulcey AE, Peterca M, Adelman P, Samant R, Balagurusamy VSK, Heiney PA (2007) Helical pores self-assembled from homochiral dendritic dipeptides based on L-Tyr and nonpolar alpha-amino acids. J Am Chem Soc 129(18) 5992-6002. doi 10.1021/... [Pg.358]

Rosen BM, Peterca M, Morimitsu K, Dulcey AE, Leowanawat P, Resmerita A-M, bnam MR, Percec V (2011) Programming the supramolecular helical polymerization of dendritic dipeptides via the stereochemical information of the dipeptide. J Am Chem Soc 133 (13) 5135-5151. doi 10.1021/ja200280h... [Pg.358]

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