1.3.2- Dioxathiane 2-oxide derivatives

The enzymatic oxidation by cyclohexanone monooxygenase (CHMO) from Acinetobacter of 1,3,2-dioxathiane 2-one derivatives 84 to the corresponding 2,2-dioxides 85, which could serve as an alternative path to other sulfates of special interest, has been published <1998CC415> (Scheme 13). The oxygen transfer at sulfur is enantioselective, and, moreover, the diastereomeric 2-oxides 84a and 84b can be separated easily by flash chromatography. The resulting 2,2-dioxides 85 are obtainable in satisfactory chemical yield. 

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