Diovan HCT

Diovan HCT, molecular formula and structure, 5 154t Dioxane... 

Diovan HCT (Valsartan) Angiotensin II receptor inhibitor combination 1.0 0.8 1.0... 

VALSARTAN/HYDROCHLOROTHIAZIDE (Diovan HCT tablets 12.5 mg hydrochlorothiazide and 80 mg valsartan, tablets 12.5 mg hydrochlorothiazide and 160 mg valsartan, tablets 25 mg hydrochlorothiazide and 160 mg valsartan) Valsartan is an antihypertensive combination. Valsartan antagonizes the effect of angiotensin II (vasoconstriction and aldosterone secretion) by blocking the angiotensin-II receptor (AT, receptor) in vascular smooth muscle and the adrenal gland, producing decreased BP. Hydrochlorothiazide (HCTZ) increases chloride, sodium, and water excretion by interfering with transport of sodium ions across renal tubular epithelium. They are used in hypertension. 

Another common drug based on sulfonamide chemistry is hydrochlorothiazide, which is sometimes abbreviated HCT or HCTZ. Hydrochlorothiazide is a diuretic that inhibits the kidney s ability to retain water. This reduces sodium levels, and hydrochlorothiazide is used for hypertension and other treatments such as the prevention of kidney stones. Hydrochlorothiazide is used in combination with various angiotension II antagonists in brand-name drugs such as DIOVAN HCT (Novartis Pharmaceuticals Corporation), HYZAAR (Merck Co. Inc.), BENICAR HCT (Daiichi Sankyo Inc.), AVALIDE (Bristol-Myers Squibb Sanofi-Synthelabo Partnership), and MICARDIS HCT (Boehringer Ingelheim Pharmaceuticals, Inc.). 

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