Diorganozinc reagents functionalized

Scheme 11.23. Preparation of various functionally substituted aminocyclopro-panes from diorganozinc reagents 80 and N,N-dialkylcarboxamides [119],...

The related zinc cuprates formed from diorganozinc reagents and copper(I) cyanide also undergo smooth SN2 substitution reactions with propargyl oxiranes in the presence of phosphines or phosphites (Scheme 2.12). These transformations can also be performed with catalytic amounts of the copper salt since no direct reaction between the organozinc reagent and the substrate interferes [31, 34], and therefore should also be applicable to functionalized organozinc compounds. 

Functionalized diorganozinc reagents [AcO(CH2)4]2Zn and [Et02C(CH2)3]2Zn were also employed, giving complete y selectivity in both cases, with ees of 50%. 

The Ni-catalyzed hydrozincation of alkenes has been reported, leading to functionalized diorganozinc reagents (Scheme 4.21) [89,94]. This reaction is particularly... 

Further applications to the preparation of chiral polyoxygenated molecules ]302] and to the synthesis of the natural product (-)-mucocin [303] have been reported. The enantioselective addition of the functionalized diorganozinc reagent... 

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