2-Nitro-13-diols

These hydroxyl groups are often called silanol groups. These predominantly bind analytes by polar interactions. Other stationary phases are also used, such as aluminum oxide or chemically modified silica gel. In the latter case usually amino, diol, nitro, or cyano group containing chemicals are reacted with the free silanol groups to modify their binding properties. 

The nitro alcohols generally are soluble in water and in oxygenated solvents, eg, alcohols. The monohydtic nitro alcohols are soluble in aromatic hydrocarbons the diols are only moderately soluble even at 50°C at 50°C the triol is insoluble. 

It has been found that the simplest method of preparing 5-nitro-tetrahydro-l,3-oxazine derivatives consists in warming 2-alkyl-2-nitropropane-l,3-diol with formaldehyde and ammonia or primary amines ... 

The reaction of ct-nitrocycloalkanones v/ith an aqneons solution of formaldehyde in the presence of potassium carbonate affords 2-nitro-l,3-diol-Oj-alkanoic acids fEq 5 21 ... 

Nitrodibenz[6,/]oxepin is converted to 2-nitro-10,ll-dihydrodibenz[6,/]oxepin-cw-10,ll-diol with osmium(VlII) oxide in benzene/pyridine.107... 

A variety of 1,5-dialdehydes 9 react in a double nitroaldol reaction with nitroalkanes to give 6-membered carbo- and heterocyclic owMran. -2-nitro-l,3-diols 10 which can be transformed into the enantiomcrically pure derivatives via enantiosclcctive saponification of their diacetates with pig liver esterase5. 

Neopentryl. 2-Nitro-2(3, 5f-dinitrophenyl). propane-diol-1,3-Dinitrate. Its power is reported as 133% of TNT... 

Nitroparaffins, Explosives Derived From. Although mononitroparaffms are generally not expl, they can be used for the prepn of expls Aaronson (Ref 1) nitrated nitroisobutyl-glycerin to Nitroisobutylgjycerintrinitrate, 2-nitro-2-methyl-l,3-propane diol to 2-Nitro-2-methyl-l, 3-propanedioIdinitrate, and 2-nitro-2-methyl-l-propanol to 2-Nitro-2-methyl-l-pro-panolnitrate. Their prepn and characterization follow ... 

Preparation of 2-Nitro-2-methyl-1,3-propane-dioldinitrate. 50g of the dry ground diol prepd... 

Nitro-2-(3-nitrophenyl)-propanediol-1,3-dinitrate (2-Nitro-2-(m-nitrophenyl)-propane-l, 3-diol-dinitrate). (02N)C6H4. C(N02) (CH20N02)2, mw 332, N 16 %, OB to C02 -57.8%, pale yel acicular prisms, mp 71—73.6°. Can be prepd by nitrating 2-nitro-2-(3 r-nitrophenyl)-propanediol-1, 3 with mixed nitric-sulfuric acid, as described in Ref 2, p 23. Sol in most common organic solvents... 

Another commonly used bactericide is 2-bromo-2-nitro-propane-1,3-diol. 

D-threo-2-Amino-3-hydroxy-3- — v-threo-2-Amino-1 - (4-nitro-phenyl)-propan-diol-( 1,3)4 ... 

HO H ChN- -O-O-OOOOtHs H NH2 — D-threo-2-Amino-l-(4-nitro-phenylj-propan-diol-(I,3)5 87% d.Th. F 163-164°... 

The conformations of the 1- and 3-nitro-BaP metabolites were determined through analysis of their NMR spectra (145-146). Both 1- and 3-nitro-BaP-trans-7,8-dihydrodiols existed predominantly in quasi-diequatorial conformations, which corresponds to the preferred conformation of the proximate carcinogen BaP-trans-7,8-dihy-drodiol (149). This suggests that these dihydrodiol metabolites may be converted into electrophilic diol epoxides and in support of this contention, the stereochemistries of 1- and 3-nitro-BaP-... 

Tiffeneau rearrangement, 34, 19 Tiglic aldehyde, diethyl acetal, 32, 5 Tin, tetraethyl-, 36, 86 Tin tetrachloride, 36, 87 o-Tolualdehyde, 30, 99 TOLUENE-a,a-DIOL, 0-NITRO-, DIACETATE, 36, 58... 

Directed osmylation.J One step in a synthesis of the carbonucleoside aris-teromycin (3) required dihydroxylation of the intermediate 1, in which a (nitro-phenylsulfonyl)methyl group is used as a carboxy equivalent. The desired diol (2)... 

Three new centers of dissymmetry are formed on cyclization of a dialdehyde with nitroethane, hence — depending on the type of substitution of the dialdehyde — three, six or eight diastereomeric methyl-nitro-diols (2, R = CHs) can be expected a priori. In view of the analogy of this reaction to the dialdehyde-nitromethane-cyclization, which is endowed with a marked stereoselectivity, the thermodynamically more stable isomers should arise in considerable preponderance. The steric effects determining the orientation of the hydroxyl groups can reasonably be assumed to be the same, thus an e,c-arrangement (4) or (5) is to be expected for the major products. 

The nitroethane cyclization of p-phenylglutaraldehyde (19) takes an analogous steric course. Only the major product, lf-methyl-l-nitro-4c-phenyl-cyclohexane-2c,6c-diol (20) was isolated in 50% yield >. The... 

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