Dinitroaniline sulfonamide

Orbencarb thiocarbamate Oryzalin dinitroaniline, sulfonamide Ovex see Chlorfenson Oxabetrinil oxime... 

Bhattacharya G, Salem MM, Werbovetz KA. Anitleishmanial dinitroaniline sulfonamides with activity against parasite tubulin. Bioorg Med Chem Lett 2002 21 2395-2398. 

George TG, Johnsamuel J, Delfin DA et aL Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides. Bioo Med Chem 2006 14 5699-5710. 

In dinitroanilines (3), R2 is usually hydrogen, while R3 and R4 are alkyl or substituted alkyl groups containing at least four carbons in total. Where R, is trifluoromethyl or alkyl, the compounds are lipophilic and have a high vapor pressure (e.g., trifluralin R, = CF3, R2 = H, R3 = R4 = CH2CH2CH3 log Xow 5.3). Where Ri is a mesyl (nitralin) or sulfonamide (oryzalin), the compounds are less lipophilic (log Kow4.0-4.7) and the vapor pressure is much less. 

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