3.6- Dimethyl-2-pyrazinecarboxylic acid

Pyrazinecarboxylic acid has been obtained by selenious acid oxidation in pyridine of methylpyrazine or aqueous permanganate oxidation of ethylpyrazine, in yields of 64 and 48%, respectively.171,218 It has also been obtained in 70% yield by partial decarboxylation of pyrazine-2,3-dicarboxylic acid on heating in vacuo at 210°.219 Aqueous permanganate oxidation of 2,5-distyrylpyrazine gives the 2,5-dicarboxylic acid.220 Pyrazine-2,5-dicarboxylic acid has also been prepared in 45% yield by direct carboxylation of pyrazine with carbon dioxide at 50 atm pressure at 250° for 3 hours in the presence of a potassium carbonate and calcium fluoride catalyst.221 Pyrazine-tricarboxylic acid (57), obtainable in only very poor yields by oxidation of 2,5-dimethyl-3-ethylpyrazine, is prepared in 87% yield by alkaline permanganate oxidation of 2-(D-arabo)tetrahydroxybutyl-quinoxaline (56).222 Decarboxylation of the tricarboxylic acid by... [Pg.141]

Benzamidopropionic acid (95) underwent unsymmetrical self-condensation and aminolysis to give l-benzoyl-2,5-dimethyl-6-methylimino-3-phenyl-l,2,5,6-tetrahydro-2-pyrazinecarboxylic acid (97), possibly via intermediate (96) (MeNH2-POCl3, CHC13, reflux, 5 h 43%) several analogues were made similarly.1098... [Pg.16]

Amino-5-dimethylamino-2-pyrazinecarboxylic acid 3-Amino-6-dimethylamino-2-pyrazinecarboxylic acid 3-Amino-5-dimethylamino-2,6-pyrazinedicarbonitrile 5-Amino-6-dimethylamino-2,3-pyrazinedicarboxamide 3- Amino-6-(3,3-dimethylbut-1 -ynyl)-2-pyrazinecarbonitrile 3-Amino-/V, /V -dimethyl-2-pyrazine-carbohydrazide... [Pg.361]

Amino-5,6-dimethyl-2-pyrazinecarbohydrazide 3-Amino-5, /V-dimethyl-2-pyrazinecarboxamide 3-Amino-5,6-dimethyl-2-pyrazinecarboxamide 3-Amino-5,6-dimethyl-2-pyrazinecarboxylic acid 3 Anniio-5.6 dimelliyi 2(1//) pyTn/iiK thione... [Pg.361]

Dimethylamino-2-pyrazinecarbonitrile 6-Dimethylamino-2-pyrazinecarbonitrile 6-Dimethylamino-2-pyrazinecarboxamide 6-Dimethylamino-2-pyrazinecarboxylic acid 2-Dimethylaminopyrazine 1-oxide 2-Dimethylaminopyrazine 4-oxide 6-Dimethylamino-2,3,5-pyrazinetricarbonitrile 2-Dimethylamino-3,5,6-trifluoropyrazine 2-Dimethylamino-3,5,6-trimethylpyrazine Dimethyl 3,6-bis(methoxycarbonylmethyl)-... [Pg.410]

Hydrazinocarbonyl-2-pyrazinecarboxylic acid 2-Hydrazino-5,6-dimethyl-3-propylpyrazine 2-Hydrazino-3,5-dimethylpyrazine 2-Hydrazino-3,6-dimethylpyrazine... [Pg.425]

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