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1.3- Dimethyl-5-nitroso-6- uracils

Amino[2- C]uracil (301. accessible from ethyl cyanoacetate and [2- C]urea as previously mentioned, is one of the key intermediates in the Traube-type synthesis of labeled uric acid and xanthine, whose methyl homologues are important biologically active natural products. Nitrosation at C5 with nitrous acid and reduction of the nitroso group with sodium dithionate installed the 5-amino group. Heating of the resulting 5,6-[2- C]diaminouracil (441 in formamide or formic acid resulted in the initial formation of the iV-formamide at C5, which cyclized with elimination of water to afford [2- C]xanthine (451 ". (V-methylation with dimethyl sulfate in basic medium under adequate reaction conditions enabled the separate preparation of [2- C]theobromine ... [Pg.471]

See other pages where 1.3- Dimethyl-5-nitroso-6- uracils is mentioned: [Pg.287]    [Pg.287]    [Pg.357]   
See also in sourсe #XX -- [ Pg.82 , Pg.287 ]

See also in sourсe #XX -- [ Pg.82 , Pg.287 ]

See also in sourсe #XX -- [ Pg.82 , Pg.287 ]

See also in sourсe #XX -- [ Pg.82 , Pg.287 ]



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1.3- Dimethyl uracil

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