Dimethyallyl pyrophosphate

Figure 26.10. Squalene Synthesis. One molecule of dimethyallyl pyrophosphate and two molecules of isopentenyl pyrophosphate condense to form famesyl pyrophosphate. The tail-to-tail coupling of two molecules of famesyl pyrophosphate yields squalene.

The condensation of dimethyallyl pyrophosphate, an isomerization product of isopentenyl pyrophosphate, with isopentenyl pyrophosphate, has been shown to yield geranyl pyrophosphate (Lynen et al., 1959). The enzyme, isopentenyl pyrophosphate isomerase, has been described (Agranoff et al., 1960). Geranyl pyrophosphate may condense with another molecule of isopentenyl pyrophosphate to yield farnesyl pyrophosphate. The enzyme farnesyl synthetase had been isolated by Lynen et al. (1959). The reductive dimerization of two molecules of... 

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See also in sourсe #XX -- [ ]

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