2.2- Dimethy 1-1 -propanol

CN 1 - [(1,1 -dimethy lethy l)amino]-3- [2- [(tetrahydro-2-furanyl)methoxy ]phenoxy ]-2-propanol... 

L. M., Smith, P. J., and Baker, M. A., Comparison of antimicrobial activity of nuclear substituted aromatic asters of 5-dimethy-lamino-l-phenyl-3-pentanol and, 3-dimcthy-lamino-1-phenyl-1-propanol with related cyclic analogs, J. Pharm. Sci., 65, 38, 1976. 

Komori and Nonaka [499] reported the first example of an electrochemical enantiomer-differentiating reaction When racemic 2,2-dimethyl-1-phenyl-1-propanol was oxidized at a poly(L-valine)-coated anode, 43% optically pure (S)-(—)-2,2-dimethy 1-1-phenyl-1-propanol was recovered as an unreacted part. Yamagishi and Aramata [500] also found electrooxidative optical resolution of a racemic Co(l,10-phenathroline)3 complex by a chiral clay-coated anode, and Yoshinaga and coworkers [501] electrore-ductively resolved racemic Co(acetylacetonato)3 by using optically active supporting electrolytes. 

Properties 1-Pentanol 2-Pentanol 3-Pentanol 2-Methyl-1 -butanol 3-Methyl-1 -butanol 2-Methyl-2 -butanol 3-Methji-2 -butanol 2,2-Dimethy -1-propanol... 

This resolution method was found to be appUcable to some cyanohydrins 15 and secondary alcohols 16. Very interestingly, the racemic cyanohydrins were converted into a pure optically active isomer in almost quantitative yield in the presence of 72 For example, when a solution of racemic l-cyano-2,2-dimethy 1-1-phenyl-propanol 15a) (1.0 g, 5.3 mmol) and 72 (2.1 g, 5.3 mmol) in methanol (2 ml) was kept in an uncapped flask for 24 h at room temperature, a brucine inclusion compound of 94% ee of +yi5a was obtained in quantitative yield, which upon decomposition gave 94% ee of - -)-15 a (1.0 g). Repeating inclusion formation of the 94 % ee containing (ri- )-75a (1.0 g) Avith 72(2.1 g) one more time yielded 100 % ee of (+)-15a [1.0 g, [a]jj -1- 15.9° (c 1.0 in MeOH)]. The process of the complete conversion of racemic cyanohydrin to one enantiomer consists of racemization of cyanohydrin through the equilibrium in Equation 1 and selective inclusion of one enantiomer in brucine... 

An almost complete resolution was attained between unlabeled and di-, tri-, or tetradeuterated drugs active on the central nervous system -l,2,3,4,10,14b-hexahydro-2-methyl- dibenzo [c,/]py-razino[l,2-fl]azepine (mianserin [VII]) and 1,3,4, 10,14b-hexahydro-2,7-dimethy l-2H-dibenzo [c,f -py-razino[l,2fl]oxazepine (Org GC 94 [VIII]). [3,3,-4,4- H4]Org GC 94 was chromatographed on p-Porasil column and n-hexane-2-propanol (90 10, v/v) to which a solution of 4% ethanol and 0.1%... 

Add-catalyzed rearrangement of 2,2-dimethy I -1-propanol (neopentyl alcohol)... 

Loras, S. Aucejo, A. Munoz, R. Isobaric vapor-liquid equilibrium in the systems methyl 1,1-dimethy-lethyl ether -1- 2-methyl-2-propanol and methyl 1,1-dimethylethyl ether -1- 2-methylpentane -1- 2-methyl-2-propanol. J. Chem. Eng. Data 1999, 44, 1169-1174. 

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