2.2- dimethoxyethyl phenyl

Dihydrocinnoline derivative 235 could be synthesized from the [2-(2,2-dimethoxyethyl)phenyl]hydrazine 234 via acid-catalyzed cyclization in dioxane. When methanol was used as solvent, a 3-methoxy-l,2,3,4-tetrahydrocinno-line 236 was formed (Scheme 62) <1995LA1303>. 

R2Tc2 + NaBH4/CH3OH HjCO 1 H3C0—CH — CHj —Br 2,2-dimethoxyethyl phenyl tellurium 80 oil - - 8... 

In 2010, the Passerini-3CR was used in the context of polymer science for the first time as a synthetic tool for the formation of mOTomers. Here, a Passerini-type condensation reaction of water, 2-(2,2-dimethoxyethyl)phenyl isocyanide... 

Moreover, the use of the convertible 2-(2,2-dimethoxyethyl)phenyl isocyanide in the Ugi-4CR enabled interesting post-polymerization modification opportunities [22]. Similarly to the use of Passerini monomers, many grafting-onto reactions could be realized using primary and secondary amines or lithium hydroxide to afford the corresponding amide- or carboxylic acid-functionalized polymers, respectively. Interestingly, the conversion into the amide was not possible via the Passerini approach as a result of the weak polyester backbone. However, because Ugi CR-derived polymers contain amide bonds, harsher reaction conditions are... 

However, the alkoxy groups in 2-dimethoxyethyl phenyl tellurium could be exchanged upon treatment with an alcohol in the presence of a small amount of hydrochloric acid3. The yields of these reactions, carried out on a 0.15 mmolar scale, were approximately 30%. 

Heating l-(2-hydroxyethyl)-2-(Taryl-l-hydroxymethyl)-3-bcnzyloxy-l, 4-dihydro-pyridinH-oncs and l-(2,2-dimethoxyethyl)-2-[1-phenyl-1-(2-pyranyloxy)methy l]-3-bcnzy loxy-1,4-dihydropy rid inM-onc in acidic media gave... 

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