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Dimenhydrinate

Dimenhydrinate. Dimenhydrinate [523-87-5] (Dramamine) (18) is a white crystalline, odorless powder that melts between 102 and 107°C. It is sparingly soluble in water, freely soluble in ethanol and chloroform, and sparingly soluble in diethyl ether. Dimenhydrinate is prepared by combining dimethylaminoethyl ben2hydryl ester with 8-ch1orotheophy11ine and refluxing in an isopropyl alcohol solution. The crystalline precipitate of dimenhydrinate that forms on cooling is collected by filtration, washed with cold ethyl acetate, and dried. [Pg.204]

Dimenhydrinate is an antiemetic especially usehil as an antinauseant in motion sickness, and for syndromes associated with vertigo such as Meniere s syndrome, radiation sickness, and vestibular dysfunction. It may produce mild drowsiness. It is FDA Category B for Pregnancy, and is available as an OTC preparation as well as by prescription. [Pg.204]

Dyazide - Hydrochlorothiazide Dyazide - Triamterene Dycill Dicloxacillin sodium Dyclone Dyclonine HCI Dyflex - Dyphylline Dygratyl Dihydrotachysterol Dylate - Papaverine monophosadenine Dymadon - Acetaminophen Dymelor - Acetohexamide Dymenol Dimenhydrinate Dymoperazine - Trifluoperazine Dynalase - Chlorpropamide... [Pg.1695]

When ondansetron is administered with rifampin, blood levels of ondansetron may be reduced, decreasing the antiemetic effect. Dimenhydrinate may mask the signs and symptoms of ototoxicity when administered with ototoxic drugp, such as the aminoglycosides (see Chap. 10), causing irreversible hearing damage. When lithium is administered with prochlorperazine, the risk of extrapyramidal reactions increases (see Chap. 32). [Pg.311]

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