Diisopropylphosphino ferrocene

Krische et al. used Ru catalysts for the addition of allyl equivalents such as ahenamides or conjugated dienes to alcohols or carbonyl compounds. The exposure of alcohols 214 to ahenamides 215 in the presence of RuHCl(CO)(PPh3)3 and the ligand dippf (bis(diisopropylphosphino)-ferrocene) results in hydrogen... 

Scheme 6 Alcohol-mediated hydrohydroxyalkylation of allenes. Yields are of material isolated by flash chromatography on silica geL Diastereoselectivity was determined through H NMR analysis of crude reaction mixtures, dippf = i is-(diisopropylphosphino)ferrocene...

Conditions using Pd(OAc)2/l,l -bis(diisopropylphosphino)-ferrocene (DiPPF) as the catalyst are also very efficient for the coupling of aryl bromides and chlorides with a variety of aliphatic thiols including HSTIPS (eq 10). ... 

Finally, allene derivatives were also convenient unsaturated substrates allowing carbon-carbon bond formation from benzylic alcohol via hydrogen transfer processes. With these substrates, the best catalytic systems were based on RuHCl (CO)(PPh3)3 in the presence of an equimolar amount of phosphine ligand such as bis(diisopropylphosphino)ferrocene (dippf) [63], bis(dicyclohexyphosphino) ferrocene or PCyPh2 [64], Some examples of selective formation of homoallylic alcohols using this reaction are reported in Scheme 59. 

A triple bond promotes ortho C—H activation by coordination and participates the hydroarylation in an o-alkynyl biaryl system. The reaction of 2-(phenylethynyl)biphenyl in the presence of Pd(OAc)2 (5 mol %) and 1,P-(diisopropylphosphino)ferrocene (d-i-Prpf, 7 mol %) in toluene at 120 °C gives 9-benzylidene-9H-fluorene in 98% yield (Scheme 18.21) [20]. This intramolecular hydroarylation proceeds via 5-exo-dig carboeyclization, being different from electrophilic activation of the triple bond followed by 6-endo-dig carboeyclization. 

Pd(OAc)2 and l,l -bis(diisopropylphosphino)ferrocene (DzPPF) (toluene, 60 °C, 2 h) as the optimized reagents and conditions for the eompletely p-stereoselective, preparation of C-glycosyl derivatives type 6 (Seheme 2). This reaction was applied to the stereoselective preparation of a range of p-C-glycosyl derivatives 6a-e, which could be obtained in moderate to good yields (Scheme 2). ... 

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