5.6- Dihydroxy-7-iodo-1-methylindole

One of the main products in each case was the expected 5,6-dihy-droxy-7-iodoindole,70,109,119, 1B1,166 which was invariably accompanied by some of the corresponding deiodinated product.1BB (The elimination of the halogen atom in reactions of this type has been referred to previously.109) Reduction of 7-iodoadrenochrome (12) with Na2S204 gives, besides 5,6-dihydroxy-7-iodo-V-methylindole (55) and 5,6-dihydroxy-iV-methylindole (28), the sodium bisulfite... 

Reduction of 7-iodoadrenochrome (12) with glutathione gave a complex mixture of products.155 The main product appeared to be chromatographically similar to the glutathione-5,6-dihydroxy- -methylindole complex obtained from adrenochrome (cf. 64B or 65B). However, both the expected 5,6-dihydroxy-7-iodo-lV-methylindole (55) and the corresponding deiodinated product (28) were also detected in the reaction mixture,155 together with a compound which is possibly... 

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