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Dihydropyrimidinones bicyclic

Scheme 7.49 Preparation of bicyclic dihydropyrimidinones employing cyclative cleavage. Scheme 7.49 Preparation of bicyclic dihydropyrimidinones employing cyclative cleavage.
A comprehensive study has investigated multidirectional cyclative cleavage transformations leading to bicyclic dihydropyrimidinones [61]. This approach required synthesis of 4-chloroacetoacetate resin as the key starting material this was prepared by microwave-assisted acetoacetylation of commercial available hydroxymethyl polystyrene resin under open-vessel conditions. This resin precursor was subsequently treated with urea and a variety of aldehydes in a Biginelli-type multi-component reaction, leading to the corresponding resin-bound dihydropyrimidinones (Scheme 16.40). The desired furo[3,4-d]pyrimidine-2,5-dione scaffold was obtained by a novel procedure for cyclative release under the action of micro-wave irradiation in sealed vials at 150 °C for 10 min. [Pg.751]

Scheme 16.40. Preparation of bicyclic dihydropyrimidinones via cyclative cleavage. Scheme 16.40. Preparation of bicyclic dihydropyrimidinones via cyclative cleavage.

See other pages where Dihydropyrimidinones bicyclic is mentioned: [Pg.103]    [Pg.329]    [Pg.103]    [Pg.66]    [Pg.284]    [Pg.103]   
See also in sourсe #XX -- [ Pg.330 ]




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