Dihydropteridinones, fluorous synthesis

Dichloro-2( lff)-pyrazinones 273 Dihydropteridinones, fluorous synthesis, cyclative cleavage 113... 

Fluorous Synthesis of Dihydropteridinones by Microwave-Assisted Cyclative Cleavage... 

The synthesis of N-alkylated dihydropteridinones 34 started with a displacement reaction of 4,6-dichloro-5-nitropyrimidine with a fluorous amino-ester (Scheme 23) [53]. The compounds formed 35 were then reacted with secondary amines to yield 36. The reduction of the nitro group of 36 was conducted by hydrogenation using Pd on charcoal as a catalyst. The cyclization reactions of 37 were promoted by microwave irradiation. The N-alkylation reaction of the cyclized products 38 with benzyl halides gave monobenzylated... 

FIGURE 1.6 Fluorous amino acid-facilitated synthesis of Af-aUcylated dihydropteridinones. 1.3.6.1.7 Fluorous Multicomponent Reactions... 

---