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Dihydroartemisinic acid, artemisinin synthesis

Scheme 6.268 shows the synthesis of the antimalarial drug artemisinin (564) from dihydroartemisinic acid (565) photooxygenation of 565 in the presence of Methylene Blue gives 566, which is oxidized by ground-state oxygen in 30% chemical yield.1462... [Pg.420]

Peter Seeberger at the Max-Planck-Institute of Colloids and Interfaces in Potsdam accomplished in 2012 a comparable synthesis, where dihydroartemisinic acid is converted to artemisinin in a flow apparatus with photochemically produced singlet oxygen. [480]... [Pg.465]

Figure 6.52 Flow scheme of the setup used for the continuous synthesis of artemisinin (115) from dihydroartemisinic acid (111). (Reproduced from Ref [47] with permission ofWiley-VCH... Figure 6.52 Flow scheme of the setup used for the continuous synthesis of artemisinin (115) from dihydroartemisinic acid (111). (Reproduced from Ref [47] with permission ofWiley-VCH...
See other pages where Dihydroartemisinic acid, artemisinin synthesis is mentioned: [Pg.1455]    [Pg.1455]    [Pg.288]    [Pg.900]    [Pg.288]    [Pg.189]    [Pg.389]    [Pg.405]    [Pg.463]    [Pg.185]    [Pg.4624]    [Pg.174]    [Pg.432]    [Pg.381]   
See also in sourсe #XX -- [ Pg.288 , Pg.289 ]



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Artemisinin

Artemisinins

Dihydroartemisin

Dihydroartemisinic

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