6- -3,4-dihydro-2//pyrimido isoquinoline, inhibition

Selective inhibition of cyclic AMP-dependent protein kinase by isoquinoline derivatives, among them by ethyl 4,6-dioxo-l,4-dihydro-6//-pyrimido[l,2-b]isoquinoline-3-carboxylate (199) and 4-amino-6-oxo-6//-pyrimido[l,2-h]isoquinoline-3-carboxylate and 3-nitrile (201), was investigated (96MI7). 

Methoxyphenyl)-3,4-dihydro-27/-pyrimido[2,1 -a]isoquinoline exhibited good inhibition of melanocortin-4 receptors (01MIP5). /V-Methyl-11 -oxo-11 //-pyrido[2,l- ]quinazolin-7-carboxamide did not exhibit any MAO A and B inhibitory activities (97JMC2466). 

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