2-2 -difluorodiethyl sulphate

Naphthyl 2-fluoroethyl ether was readily prepared by warming an alkaline solution of 2-naphthol with 2 2 -difluorodiethyl sulphate. Subcutaneous injection into mice of the propylene glycol solution showed that the compound had a l.d. 50 of approximately 60 mg./kg. and was therefore much less toxic than M.F.A. 

On exposing animals for 10 min. to 0-327 g./cu.m. of the chlorosulphonate, irritation was observed and rats showed the same type of convulsions as with M.F.A. However, only 2/13 of a batch of rabbits, guinea-pigs and rats died within 24 hr. The difluorodiethyl sulphate was non-irritant and less toxic. It proved to be a good fluoroethylating agent. 

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