1,5-Difluoro-2,4-dinitrobenzene

P Marfey. Determination of D-amino acids, n. Use of a bifunctional reagent 1,5-difluoro-2,4-dinitrobenzene. Carlsberg Res Commun 49, 591, 1984. 

Difluoro-2,4-dinitrobenzene, 2073 Difluorotrifluoromethylphosphine oxide, 0359 Dimethyl /V,/V-dichlorophosphoramidate, 0897... 

If 1,5-difluoro-2,4-dinitrobenzene is used as the activated halogen compound, then in boiling DMF solution a double ring-closure to the tetraphenyl-17/,9//-benzo[l,2-c 5,4-e ]bi-s[l,3,4]thiadiazine (294) (14%) is noted. 2,4-Dinitrofluorobenzene also undergoes reaction with dithizone (PhN=NCSNHNHPh) in acetonitrile at 25 °C to yield 6-nitro-l-phenyl-3-phenylazo-l//-4,l,2-benzothiadiazine (293) as purple needles in 79% yield (see also Section 6.17.7.1.3). 

Analytical techniques enabling polymers to be accurately structurally described are of the greatest importance, and the quantitative analysis of copolyamides (and copolyesters) by gas chromatography is now possible. A method for the determination of the degree of cross-linking in nylon-6 and -66, using 1,5-difluoro-2,4-dinitrobenzene has been reported, and kinetic studies on gel formation in molten poly(n-xylylene adipamide) have also been carried out. ... 

DNP-pyridoxamine-P is prepared in the same way as FDNP-pyri-doxamine-P, but with 2,4-dinitrofluorobenzene instead of 1,5-difluoro-2,4-dinitrobenzene. 

Oxacalixarenes containing axially chiral elements have been synthesized using BINOL and the electrophiles 1,5-difluoro-2,4-dinitrobenzene 7 or cyanuric chloride 10. Likely due to increased macrocycle flexibility, the ( )-BINOL-derived oxacalixarenes 41 (mixture of stereoisomers) are formed kinetically, but equilibration experiments reveal that they are not the thermodynamically favored products (Fig. 15.6) [85]. The analogous macrocycles derived from enantiopure BINOL and cyanuric chloride 10 demonstrated high enantioselective fluorescence responses to a-amino acids [86]. 

---