Differential scanning calorimetry lipids studied using

Differential Scanning Calorimetry has been used for studying the interaction of labdanes 1 (labd-13(E)-ene-8o,15-dio1), 2 (labd- 3(E)-cne-8u-ol-15-yl-acetate) and 3 (labd-14-ene-8,13-diol (Sclareol)) Fig. (12) [76-77] with DPPC model lipid bilayers. The thermotropic changes caused by the labdanes in DPPC bilayers could be used for evaluating the incorporation efficiency of labdanes in DPPC liposomes. Furthermore in these studies [29, 76], a comparison with die structurally similar molecule to cholesterol was carried out based on their thermotropic behavior. The development of liposomal formulations incorporating 1 and 2 has been achieved, while the stability studies of the liposomal formulations based on -potential and on liposomal size have been evaluated. 

Differential scanning calorimetry is widely used to obtain phase information. Many phase diagrams are inferred from calorimetric data jointly with some other techniques. Calorimetry has been used extensively for physical studies of polar lipids and provides invaluable information about the numerical values of the thermodynamic variables [9]. A sample cannot be viewed during calorimetric studies, but in combination with observations in hot stage microscopy (with common and/or polarized light) the nature of phase transitions and their temperature can be determined. 

Champan, D., Urbina, J., and Keough, K. M. (1974), Studies of lipid water systems using differential scanning calorimetry,/. Biol. Chem., 249(8), 2512-2521. 

Differential scanning calorimetry is a well known technique in the study of the thermal behavior of lipids and can be used to assess purity and stability of lipids, perturbation of aggregate structures, phase transition temperatures, lipid mixing behavior, and influence of other molecules and ions on structure. ... 

McElhaney, R.N. (1982). The use of differential scanning calorimetry and differential thermal analysis in studies of model and biological membranes. Chem. Phys. Lipids 30 229-259. 

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