Different Methods for Preparing the Powder Mass

As an addition to the general method of preparation of a powder mixture, for capsules some specific directions apply. Capsules are filled by volume, therefore, the powder mixture should be prepared to obtain a specific volume. The correct volume depends on the capsule size and the number of capsules to be filled (Table 4.3). 

Smaller capsule sizes should not be prepared in small batches, because a relatively large loss during mixing and filling may result in a too low content. Moreover, the mass deviation and thereby content deviation may become too large for such batches, because a small quantity of powder is hard to divide evenly over the capsules. 

Four methods will be described for the preparation of powder mixtures for capsules. These methods are about mixing of varying ratios and the preparatiOTi of a powder mixture from capsules and tablets. 

Active substance and dose Solvent and amount Deposition and ratio Diluent Reference 

Colchicine Methylene chloride 2x9 mL for 162 mg colchicine Diluent 100 times the amount of colchicine Microcrystalline cellulose [31] 

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