Diethylaminosulphur trifluoride DAST and related reagents

Such is the versatility of DAST and related reagents that many fluorinated derivatives of natural products, including steroids, carbohydrates, nucleosides, prostaglandins and vitamin D analogues, amongst others, have been successfully synthesised [10, 16, 17] (Table 3.5). 

Generally, sulphur tetrafluoride can only be used for fluorodehydroxylations of acidic alcohols, otherwise extensive decomposition to side-products predominates. However, (3-fluoroamino acids can be prepared by such a process [7]. 

---