Diethyl phosphorothionochloridate

Several methods of preparing sulfotep are known. The process developed by Schrader, which is also used industrially, based on the partial hydrolysis of diethyl phosphorothionochloridate (11) is the most important. In this reaction, sodium diethyl thionophosphate is formed, which reacts with the unreacted diethyl phosphorothionochloridate to give 10 (Schrader and Miihlmann, 1950 Schrader,... 

Parathion is prepared by a method analogous to that of paraoxon (15), the reaction of diethyl phosphorothionochloridate (11) with sodium p-nitrophenolate. 

The development of the first and still most important members of the group is linked with the name of Schrader. 0,0-Diethyl-0-(2-ethylthioethyI) phosphoro-thioate (demeton-0, 55), introduced under the name Systox , was prepared by the reaction of ethylmercaptane with ethylene oxide, and the reaction of the resulting 2-ethylthio-ethano1 with diethyl phosphorothionochloridate in the presence of an acid binder (Schrader, 1950a, 1950b). 

---

See also in sourсe #XX -- [ , ]

---