Diethyl difluoromalonate

Geminal difluorination ot diethyl diazomalonate can be effected with molecu lar fluorine (10% in nitrogen) to give diethyl difluoromalonate m 70% yield [90] (equation 27)... 

Fluorination of active-methylene compounds. The Pennsalt groups treated diethyl malonate with two equivalents of sodium ethoxide in ethanol and passed in perchloryl fluoride with cooling and reported isolation of diethyl difluoromalonate in... 

The directed fluorination reaction of diethyl malonate can be performed in a three-channel microreactor (Scheme 8.1) [8]. The synthesis offluoro- and difluoromalonate esters by the fluorination of Meldrum s acid is readily achieved in a microflow reactor without the use of added catalysts or malonate salts as substrates that are required in a conventional macrobatch reaction. 

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