2- diethoxy-phosphorylmethyl acrylic acids

There are two possibilities for converting polymer-bound 3-hydroxy-2-methylidene propionic acids into 2-diethoxy-phosphorylmethyl acrylic acids. One is the treatment of these substrates with diethyl chlorophosphite and Et3N followed by an Arbuzow rearrangement. The other method, which resulted in higher purities [28], is the reaction of acetylated 3-hydroxy-2-methylidene propionic acids with triethylphosphite in DMF for 5 h at 60°C (Fig. 6.12). Table 6.6 shows the variation of the aldehydes in this reaction. All compounds were analyzed by ES-MS and analytical HPLC. 

Table 6.6. Variation of the aldehyde in the synthesis of 2-diethoxy-phosphorylmethyl acrylic acids...

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