Diels-Alder reactions of allenes

An intramolecular Diels-Alder reaction of allenic dienamide 181 provided the tet-rahydroindole ring system 182, which was oxidized with DDQ or Mn02 to give indole derivatives [147]. 

As a first approach to the synthesis of nagilactone 296, a norditer-penoid isolated from Podocarpaceae, which inhibit the expansion and mitosis of plant cells, an intramolecular Diels-Alder reaction of allene 1,3-dicarboxylic acid esters was used. The cyclization of 297 afforded the 8-lactone 298, rather than the y-lactone 299 [85JCS(P1)747]. 

---

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

---