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Didemnin immunosuppressive activity

Didemnin B (347) is a cyclic depsipeptide isolated from the Caribbean tunicate Trididemnum solidum and is currently in phase II clinical trials as an anticancer agent. Didemnin B also shows antiviral and immunosuppressive activity. The structure of didemnin B was revised to 347 containing... [Pg.89]

Didemnins were isolated from a Caribbean tunicate Trididemnum solidum. These structurally unique cyclic depsipeptides have quite interesting cytotoxic, antiviral, and immunosuppressive activities. The synthesis of the didemnins A, B, and C (173-175) involves the key component 178, which is prepared from acid 176 and amine 177 using the coupling agent DEPC.69... [Pg.526]

Montgomery, D.W. and Zukoski, C.F. (1985) Didemnin B a new immunosuppressive cyclic peptide with potent activity in vitro and in vivo. Transplantation, 40, 49-56. [Pg.1710]

See other pages where Didemnin immunosuppressive activity is mentioned: [Pg.464]    [Pg.119]    [Pg.489]    [Pg.106]    [Pg.326]    [Pg.286]    [Pg.392]    [Pg.714]    [Pg.355]    [Pg.525]   
See also in sourсe #XX -- [ Pg.5 , Pg.421 ]

See also in sourсe #XX -- [ Pg.5 , Pg.421 ]



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