Dichothrix baueriana

Bauerines A-C (50-52) are chlorinated p-carbolines from the blue-green alga Dichothrix baueriana that show activity against herpes simplex virus type 1 [49]. 

A 6-cyano-5-methoxy-12-methylindolo[2,3-a]carbazole and 6-cyano-5-methoxyindolo[3-a]carbazole were isolated from the blue-green alga Nostoc sphaericum [95]. These compounds are active against HSV-1. Larsen ct al. [96] isolated three new chlorine-containing P-carbolines, bauerines A-C, from the blue-green alga Dichothrix baueriana. These alkaloids show activity against HSV-2. 

Sponge, Balzella sp. Blue-green alga, Dichothrix baueriana Sponge, Kirkpalrickia variolosa... 

Larsen, L.K. Moore, R.E. Patterson, G.M.L. b-Carbolines from the Blue-Green Alga Dichothrix baueriana. J. Nat. Prod. 1994,57, 419-421. 

A few indole-based compounds are active against viruses (Scheme 24). The non-nucleoside reverse transcriptase inhibitor delaviridine (163) is used in antiretroviral therapy [150]. The blue-green alga Dichothrix baueriana has yielded bauerine B (164), a dichloro p-carboline active againstherpes simplex virus type 1 [169]. Seeds of the plant Solarium indicum have yielded the new coumarinolignoid indicumine B (165), which possesses anti-hepatitis B... 

Several p-carboline alkaloids were synthesized via Fischer indole methodology. For example, the blue-green alga Dichothrix baueriana alkaloids bauerines A, B, and C were synthesized by two groups via a Japp-Klingemann approach (Scheme 43, equations 1 and 2) [282,283]. Only the routes to bauerine C (140) are shown. Bauerines A and B were prepared in poor yields by reduction of the Fischer indole lactam product and DDQ oxidation of the tetrahydro-p-carbolines. Islam s synthesis [283] of bauerine C is essentially identical to that of Bracher [282], and in roughly comparable yields. A Fischer indolization was... 

Dichothrix baueriana (Gmn.) Bomet Hahault Rivulariaceae Algae Cyanobacteria Biomass 7-chloro-9-mehtyl-P-carboline (bauerine A) 7.8- dichloro-9-mehtyl-P-carboline (bauerine B) 7.8- dichloro-lhydroxy-9-mehtyl-P-carboline (bauerine C) [28]... 

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