2, 4-Dichloroaniline

Fig. 1 Reflectance scan of a chromatogram track with 200 ng 2,3-dimethylaniline (1), 100 ng each of 4-chloro-2-methylamline (2), 3,4-dichloroaniline (3), 3,S-dichloroaniline (4) and 200 ng each of 2,3-dichloroaniline (S) and 2,S-dichloroaniline (6) per chromatogram zone.

In an analogous manner, reaction of 2,3-dichloroaniline (77-1) with nitrogen mustard gives the arylpiperazine (77-2). The remaining amine is then alkylated with 4-chlorobromobutane (77-3). Alkylation of the alkoxide from the hydroxycar-bostyril (77-4) affords the antipsychotic agent aripiprazole (77-5) [78]. 

FIGURE 11.16 Electrophorogram for a standard solution of aromatic amines. Peaks 1, pyridine 2, /7-phenylenediamine 3, benzidine 4, o-toluidine 5, aniline 6, A/,A -dimethylaniline 7, p-anisidine 8, /7-chloroaniline 9, m-chloroaniline 10, ethylaniline 11, a-naphthylamine 12, diethyl-aniline 13, A -(l-naphthyl)ethylenediamine 14, 4-aminophenazone 15, o-chloroaniline 16, 3,4-dichloroani-line 17, 3,3 -dichlorobenzidine 18, 2-methyl-3-nitroaniline 19, 2,4-dichloroaniline 20, 2,3-dichloroaniline 21, 2,5-dichloroaniline. (From Cavallaro, A., Piangerelli, V., Nerini, F., Cavalli, S., and Reschiotto, C., J. Chromatogr., 709, 361-366, 1995.)... 

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