Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Dichloroacetate, lactic acidosis

Stacpoole PW, Barnes CL, Hurbanis MD, et al. Treatment of congenital lactic acidosis with dichloroacetate a review. Arch Dis Child 77 535-541,1997. [Pg.88]

Lactic acidosis. Patients in shock will often suffer from lactic acidosis due to a deficiency of O2. Why does a lack of O2 lead to lactic acid accumulation One treatment for shock is to administer dichloroacetate, which inhibits the kinase associated with the pyruvate dehydrogenase complex. What is the biochemical rationale for this treatment ... [Pg.727]

In addition to discontinuation of the NRTT, L-car-nitine, riboflavin, and thiamine have been used in isolated reports but with unclear fherapeutic role [106, 111-113] Many of these patients have been treated with high-dose intravenous sodium bicarbonate. Hemodialysis [114] and continuous venovenous hemodiafiltra-tion [85] have been used to reduce the lactic acidosis, even in the absence of significant kidney injury. Lactic acidosis transiently and modestly improved after administration of dichloroacetate in one report [99]. The benefit of any of these therapies remains unclear. [Pg.389]

Stacpoole PW, Wright EC, Baumgartner TG, et al. A controlled clinical trial of dichloroacetate for treatment of lactic acidosis. N Engl J Med 1992 327 1564-1569. [Pg.1002]

Shangraw RE, Winter R, Hromco J, et al. Amelioration of lactic acidosis with dichloroacetate during liver transplantation in humans. Anesthesiology 1994 81 1127-1138. [Pg.1002]

The dichloroacetate ion stimulates the activity of the enzyme pyruvate dehydrogenase by inhibiting the enzyme pyruvate dehydrogenase kinase. Thus, it decreases lactate production by shifting the metabolism of pyruvate from glycolysis towards oxidation in the mitochondria. This property has led to trials of DCA for the treatment of lactic acidosis in humans. [Pg.84]

A clinical trial where DCA was given to patients of MELAS (a form of genetically inherited lactic acidosis) at 25 mg/kg/day was ended prematurely due to excessive peripheral nerve toxicity. Dichloroacetate can also have anxiolytic or sedative effects. [Pg.87]


See other pages where Dichloroacetate, lactic acidosis is mentioned: [Pg.1002]    [Pg.89]    [Pg.68]    [Pg.1002]    [Pg.89]    [Pg.68]    [Pg.373]    [Pg.375]    [Pg.469]    [Pg.510]    [Pg.992]    [Pg.993]    [Pg.481]   
See also in sourсe #XX -- [ Pg.375 ]




SEARCH



Acidosis

Dichloroacetal

Dichloroacetate

Lactic acidosis

© 2024 chempedia.info