Dicarboxylic acid monochlorides

Dicarboxylic acid monochlorides from dicarboxylic acids... [Pg.566]

Dicarboxylic acid monoesters from dicarboxylic acid monochlorides... [Pg.96]

Klein and Neff358 prepared mono- and di-ketones as well as oxo esters in excellent yield by treating alkylzinc iodides with carbonyl chlorides, dicarbonyl dichlorides, or monoester monochlorides of dicarboxylic acids. The alkylzinc iodides were obtained directly from the alkyl iodides and a zinc-copper alloy in toluene-ethyl acetate, as in the following example. [Pg.910]

Carboxylic anhydrides and alkylcadmiums give ketones in 50-70% yield 359 this reaction is also smooth with Grignard reagents, especially at low temperatures (—70°).365 Oxo carboxylic acids are obtained when alkylcadmiums or alkylzincs are treated with cyclic acid anhydrides359,366,367 or when a monoester monochloride of a dicarboxylic acid reacts with an isoalkyl-magnesium bromide.368 (The oxo group can be reduced by Clemmensen s... [Pg.911]

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