Dibenzylphosphole oxide

While diphenylphosphine oxide is used in most HW reactions, attempts have been made to utilize other phosphine oxides in order to enhance Z-selectivity. For example, ortHo-substituted diarylphosphine oxides such as (anisyl)2P(0)CHPr Li have been used to produce complete Z-selectivity [53]. Dibenzylphosphole oxides 15 have also been utilized by several researchers in an attempt to enhance stereoselectivity [51, 54, 55]. 

While diphenylphosphine oxide has been employed most frequently to activate the carbon nucleophiles in the Homer-Wittig reaction, alternative use of bis(o-anisyl) phosphine oxide [207] or dibenzylphosphole oxide [208-210] leads to better stereoselectivity for alkene synthesis (Scheme 44). 

Scheme 44 Bis(o-anisyl) phosphine oxides and dibenzylphosphole oxides...

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See also in sourсe #XX -- [ ]

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