Dibenzyl phenylphosphoramidate

The parent phenylphosphoramidic acid, PO(NHPh)(OH)2, was obtained by a method which consisted in the ready hydro-gmolysis of dibenzyl phenylphosphoramidate. An attempt to prepare dibenzyl p-dimethylaminophenylphosphoramidate by the action of AA -dimethyl-p-phenylenediamine on dibenzyl jhosphorochloridate gave only an oil. When, however, a mixture of the amine, dibenzyl hydrogen phosphite, and trichloro-Ixomomethanewas used, a good yield of thedibenzylp-dimethyl-aminophenylphosphoramidate was obtained. It is a crystalline solid which causes severe dermatitis the irritation develops slowly and with some individuals persists for weeks. 

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