Dibenzo thiadiazepines

Dibenzo[6,/][l,4,5]thiadiazepine is converted into the 5,6-dihydro derivative on treatment with hydrazine in the presence of 5% palladium on charcoal.153... 

Die Elektrolyse von 2,2 -Dinitro-diphenylsulfid an Quecksilber fuhrt in saurem Milieu zum Diamin, sonst zum Dibenzo-1,4,5-thiadiazepin, das zum 9,10-Dihydro-Derivat (Klemmenspannung 40-65 V) weiter reduziert werden kann5 ... 

Some discussion has arisen concerning the products and mechanism of the formation of dibenzo[fc/]-l,4,5-thiadiazepine derivatives from di-(2-nitrophenyl) sulfide (91). In one investigation156 it was concluded that the dibenzothiadiazepine was formed by reaction of a nitroso group with an... 

The dibenzo[l,2,5]thiadiazepines 443 and 444 have been tested for their antiproliferative activity against the L1210 leukemia cell line. Both compounds display low cytotoxicity with IC50 values of 12.7 and 29.9 pM, respectively <2004H(63)2457>. 

Dinitrobiphenyl [101-104] is thus in alkaline solution at a suitable potential, reducible to benzo[c]cinnoline-7V-oxide in acid solution the reduction proceeds to 4,5-dihydrobenzo[c]cinnoline, which is very easily (e.g., by air) oxidized to benzo[c]cinnoline. A similar ring closure during the reduction of 2,2, 6,6 -tetranitrobiphenyl yields A-oxides of 4,5,9,10-tetraazapyrene [105-107]. Reduction of 2,2 -dinitrodiphenylsulfide yields via 2,2 -(bishydroxylamino)diphenylsulfide in strongly acidic or in alkaline solution dibenzo[Z)/]-l,4,5-thiadiazepine and its iV-oxide [108] under slightly different conditions the formation of 3-hydroxyphenothiazine has been reported [109]. 

The reaction of 2,2 -diaminobiphenyl with thionyl chloride in refluxing toluene gives dibenzo[c,e][l,2,7]thiadiazepine (24). This compound is ther-... 

Thiadiazepines.- Substituted dibenzo[b,f][1,4,5]thiadiazepines have been prepared in good yields by cyclisation, via Smiles rearrangement, by heating (65) at reflux in DMF-potassium... 

The dibenzo[c,e]-1,2,7-thiadiazepine (43) can be prepared by oxidation of A(,7V -diphenylsulfamide (40) with sodium hypochlorite in the presence of a base, probably via a type of oxidative coupling mechanism involving the intermediates (41) and (42) (Scheme 5) <71JCS(C)993>. 

A new family of dibenzo[l,4,5]thiadiazepines 203 has been reported, which show promise as neuroprotective agents (14EJM350). A range of... 

An ale. soln. of 2,2 -dihydroxylaminodiphenylsulfone (prepn. s. 31) added drop-wise with cooling at 50° to a mixture of NaOCl-soln. and ethanol, then most of the ethanol distilled off, more NaOCl-soln, added, refluxed 0.5 hr., and allowed to stand 2 hrs. crude dibenzo[ 1,4,5] thiadiazepine 5,11,11-trioxide. Y 73%. K. Michel and M. Matter, Helv. U, 2204 (1961). 

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