Tacrine Diazepam

Fig. 4.3 CSF concentration/free (unbound) plasma concentration ratios for neutral and basic drugs 1, ritropirronium 2, atenolol 3, sulpiride 4, morphine 5, cimetidine 6, meto-prolol 7, atropine 8, tacrine 9, digoxin 10, propranolol 11, carbamazepine 12, ondansetron 13, diazepam 14, imipramine 15, digitonin 16, chlorpromazine and acidic drugs, a, salicylic acid b, ketoprofen c, oxyphenbutazone and d, indomethacin compared to log D.

Diazepam does not appear to affect the pharmacokinetics of tacrine or rivastigmine. 

In a small study a single 2-mg dose of diazepam did not affeet the pharmacokinetics of tacrine 20 mg every 6 hours, when compared with subjects not taking diazepam. Similarly the manufacturers of rivastigmine say that no pharmacokinetic interaction has been seen with diazepam in healthy subjects. No special precautions would seem necessary if diazepam is given with tacrine or rivastigmine. 

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