Rabeprazole Diazepam

Gait disturbances (attributed to benzodiazepine toxicity) occurred in two patients given triazoiam and lorazepam or flu-razepam with omeprazoie, and another patient taking diazepam and omeprazole became wobbly and sedated. Lansoprazole, pan-toprazole, or rabeprazole appear not to interact to a clinically relevant extent with diazepam. Diazepam serum levels are increased by esomeprazole but the clinical relevance of this is unknown. 

Information is limited, but what is eurrentiy known suggests that patients given omeprazole, and possibly esomeprazole, with diazepam may expe-rienee inereased benzodiazepine effeets (sedation, unstable gait ete). If this oeeurs the benzodiazepine dosage should be reduced. Lansoprazole, pantoprazole and rabeprazole do not appear to interaet with diazepam. 

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