Diaza octane synthesis

Scheme 54 Synthesis of (2/t,55)-l,3-diaza-2-chloro-3-phenyl-2-phosphabicyclo[3.3.0]octane 198...

A useful method for large-scale synthesis of diastereomerically pure (2R,5S)-3 -phenyl-2-(8-quinolinoxy)-1,3-diaza-2-phosphabicyclo[3.3.0]octane (205) was based on a similar reaction of tris(dimethylamino)phosphine with (5)-197a generating the intermediate 204 which, by addition of 8-hydoxyquinoline followed by additional refluxing gave the final product. Recrystallization of the crude reaction mixture afforded diastereomerically pure 205 as a solid, stable to air and moisture in 98% yield (Scheme 57) [88], It was converted to complex 206 by mixing with... 

Synthesis of 2,2,4,4-Tetra-ferf-butyl-1,3-diaza-2,4-disilabicyclo[3.3.0]octane 318... 

Cignarella, G Occelli, K Crisliani, G.. Pad-uamo, L., and Testa, H.. Bicyclic homologs of piperazine, VI. Synthesis and analgesic activity of 3-.substituted-8-propionyl-3,8-diaza-bicyclo[3.2.1 ]octanes. J. Med Chem., 6. 764. 1963. 

Swem oxidation has been used in the synthesis of homochiral 3-oxa-2,7-diaza-bicydo[3.3.0]octanes from amino adds by intramolecular 1,3-dipolar cycloaddition of nitrones [1347]. 

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